Eventually, we are all going to die. It's inevitable.
The difference between most of us and Dr. Randy Pausch is that we don't have as defined an idea as to WHEN that might happen. He has very aggressive pancreatic cancer, and it continues to return & spread. As a professor at Carnegie-Mellon University, he was given the opportunity to give a last lecture to his students before he 'retired' in order to spend more time with his family.
This past January (I believe), he reprised the talk on Oprah. This video is about 10 minutes long, but well worth watching.
You can check out Randy's home page here. He has links to his current health status, as well as links to the entire lecture.
(Thanks Jess, for posting the link to the video.)